EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation (Adv. Sci. 25/2025)
Source abstract
Abstract
Extrachromosomal Circular DNA In article number 2501934, Bin Shi, Shuyu Zhang, and co-workers present the increased existence of eccDNA induced by ionizing radiation. VPS41 gene in the eccDNA confers protection against genotoxic stress. This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to genotoxic stress.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: CRISPR and Genetic Engineering · RNA Interference and Gene Delivery · RNA regulation and disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References
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