ALKBH3‐Mediated M¹A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M¹A and M⁶A RNA Methylation (Adv. Sci. 19/2025)

Pathological Skin Fibrosis The artwork symbolises RNA modification crosstalk in skin fibrosis through Medusa and Perseus. Medusa's gaze symbolizing m6A methylation promotes fibrotic progression and transforms healthy skin into a rigid stone-like state. Perseus representing m1A methylation neutralizes this effect by reflecting her gaze and thereby inhibits fibrosis. This visual metaphor underscores m6A's detrimental role and m1A's protective function in fibrosis. More details can be found in article number 2417067 by Haizhou Li, Yixuan Zhao, Tao Zan, and co-workers.