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journal article·2025-05Open access

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury (Adv. Sci. 18/2025)

Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li

Advanced Science· Volume 12· Issue 18
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Source abstract

Abstract

Therapy for PA-Induced Acute Lung Injury In article number 2413253, Xin Yu, Yujing Song, Katsuo Kurabayashi, Yongqing Li, and co-workers discover a new chemical modification site catalyzed by an enzyme called PAD2 on the intracellular protein, NF-κB p65, which modulates immune cell (macrophage) functions. Using nanoparticle therapy to block PAD2 significantly reduced inflammation and improved outcomes in acute lung injury during bacterial infections.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Microbial Applications in Construction Materials · Inflammation biomarkers and pathways · Cancer Research and Treatments

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