Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration (Adv. Sci. 16/2025)

Mammalian Neural Regeneration Glaucoma primarily results from damage to the optic nerves. Shu-Guang Yang, Chang-Ping Li, and co-workers have made a groundbreaking discovery: deleting the histone demethylase Kdm6a in neurons increases histone methylation levels. This change alters the chromosome structure, making it more densely packed and effectively silencing the expression of regeneration suppressor genes. This study described in article number 2405537 identifies a promising new target for treating glaucoma and other retinal injuries.