Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma (Adv. Sci. 15/2025)

Irreversible Electroporation Immunotherapy In article number 2409381, Min Zhou, Zhe Tang, and co-workers present a microalgae-based drug delivery system, showcasing the oral administration of engineered microalgae carrying immunomodulators for liver cancer treatment. In synergy with irreversible electroporation technology, it activates systemic anti-tumor immunity. Through innovative collaboration between biomaterials and physiotherapy, it breaks through the limitations of traditional treatments and provides a new paradigm for precise immunotherapy of liver cancer.