Rational Design of Natural Xanthones Against Gram‐negative Bacteria (Adv. Sci. 14/2025)
Source abstract
Abstract
Gram-negative Bacteria Most antibiotics are ineffective against Gram-negative bacteria due to the presence of the outer membrane (OM). In article number 2411923, Jianzhong Shen, Kui Zhu, and co-workers screened natural xanthone skeletons with the potential to penetrate the OM after amine modification. These optimized compounds cross the OM via a self-promoted pathway, facilitating the discovery of novel antibacterial agents.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Natural Compound Pharmacology Studies · Phytochemistry and Biological Activities · Phytochemicals and Antioxidant Activities
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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