Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist (Adv. Sci. 14/2025)

CAR-T-Cell Therapy In article number 2409835 by , Beichen Liu, Yuan Gao, Huadong Zhao, and co-workers, injection hydrogels are engineered for the controlled co-delivery of CAR-T cells and BC1618 that improves the treatment of TNBC. On the cover: The ocean currents represent the delivery medium of CAR-T cells, which is the hydrogel. The schools of small fish swimming around symbolize BC1618, an agonist that can enhance the function of CAR-T cells. The shark represents tumor cells, while the narwhal represents CAR-T cells with enhanced attack power after being delivered by the hydrogel. The dolphins in the background represent regular CAR-T cells, which have relatively weaker attack power.