DataVXAdvanced SciencePaper
journal article·2025-04Open access

Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer (Adv. Sci. 14/2025)

Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang

Advanced Science· Volume 12· Issue 14
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Source abstract

Abstract

New Subtype of Small Cell Lung Cancer In article number 2413445, Dingzhi Huang, Mengjie Li, and co-workers report that a HDAC7-high small cell lung cancer (SCLC) subtype has a poor prognosis and have identified XPO1 as a druggable target in this subtype. Elevated HDAC7 predicts increased sensitivity to selinexor both in vitro and in organoids, suggesting selinexor as a promising therapeutic option for HDAC7-high SCLC patients.
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Research context

OpenAlex topics: Peptidase Inhibition and Analysis · Histone Deacetylase Inhibitors Research · Lung Cancer Research Studies

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