ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid‐Endothelial Interactions (Adv. Sci. 13/2025)

Open Microfluidic Platform The cover features an innovative open microfluidic platform that enables direct culture and analysis of tumor spheroids interacting with blood vessels, developed by Yoon-Kyoung Cho and co-workers. The image showcases the high-throughput chip where cancer spheroids (detailed in circular inset) can be grown and retrieved for genetic analysis while studying their interactions with the underlying vasculature, advancing our understanding of tumor drug resistance mechanisms. More details can be found in article number 2410659.