ShK‐modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis (Adv. Sci. 9/2025)

ShK-Modified UCMSCs Therapy for Osteoarthritis The cover illustrates the Flaming Mountains from Chapter 59 of the Chinese mythological novel Journey to the West. The intense flames of the Flaming Mountains (representing M1 macrophages) can be extinguished by a palm leaf fan (ShK-modified UCMSCs) from Princess Iron Fan, whose powerful winds (comprising secreted ShK and anti-inflammatory cytokines) quench the fire. More details can be found in article number 2406822 by Lan Li, Qing Jiang, Baosheng Guo, and colleagues.