Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis (Adv. Sci. 8/2025)

Reversion of Tumorigenesis A cell fate can be quantitatively evaluated through an attractor landscape in a high-dimensional space, governed by intricate interactions of the underlying gene regulatory network. In article number 2412503, Kwang-Hyun Cho and co-workers present a systems framework, REVERT developed to identify a reversion switch in the transition of colorectal tumorigenesis, enabling the manipulation of the attractor landscape to revert cancer cells into normal cell states.