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journal article·2025-02Open access

Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner (Adv. Sci. 7/2025)

Min Xiong, Danhao Xia, Honglu Yu, Lanxia Meng, Xingyu Zhang, Jiehui Chen, Ye Tian, Xin Yuan, Xuan Niu, Shuke Nie, Zhaohui Zhang, Chaoyang Liu, Qiang Chen, Keqiang Ye, Zhentao Zhang

Advanced Science· Volume 12· Issue 7
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Source abstract

Abstract

Parkinson's Disease In article number 2413451, Zhentao Zhang and co-workers show that microglia process α-synuclein fibrils to generate novel fibrils with enhanced toxicity, promoting the onset and progression of Parkinson's disease. α-Synuclein fibrils enter microglia through TREM2. Then they are processed by asparagine endopeptidase to produce α-synuclein 1-103 fibrils, which are more toxic than naive α-synuclein fibrils. These results show that blocking the aberrant activity of microglia halts the progression of Parkinson's disease.
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Research context

OpenAlex topics: Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Conducting polymers and applications

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