journal article·2025-02Open access

Capture of Totipotency in Mouse Embryonic Stem Cells in the Absence of Pdzk1 (Adv. Sci. 6/2025)

Wenhao Zhang, Yiding Zhao, Zhe Yang, Jing Yan, Haisong Wang, Shaochen Nie, Qingshen Jia, Dan Ding, Chao Tong, Xiao‐Ou Zhang, Qian Gao, Ling Shuai

Advanced Science· Volume 12· Issue 6

Abstract

Capture of Totipotency In article number 2408852, Ling Shuai, Qian Gao, Xiao-Ou Zhang, and co-workers report the generation of mouse totipotent-like stem cells through deletion of a single gene, Pdzk1. This novel and efficient strategy to acquire totipotency just like a beautiful genie has her powerful arrow to shoot the magic shining stars, representing the plasticity of development.
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Research context

OpenAlex topics: Pluripotent Stem Cells Research

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