Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice (Adv. Sci. 5/2025)

Proteases in Material-Induced Immune Response Proteases play a crucial role in modulating inflammation, yet their influence on immune reactions to implanted materials is understudied. In article number 2309709, Nam Tran, Anh Truong, Dang Nguyen, and Tram Dang comprehensively profile protease responses to various microparticulate materials in immuno-competent mice, revealing a strong correlation between protease activity and expression of pro-inflammatory cytokines. The cover artwork captures how different materials trigger distinct levels of protease activity, measurable as a non-invasive biomolecular signature of material-induced immune response.