SPP1⁺ TAM Regulates the Metastatic Colonization of CXCR4⁺ Metastasis‐Associated Tumor Cells by Remodeling the Lymph Node Microenvironment (Adv. Sci. 44/2024)

Oral Squamous Cell Carcinoma The cover highlights the complex process of tumor metastasis from the primary site to the lymph nodes. It illustrates how SPP1+ TAM, which are particularly prevalent in these metastatic nodes, play a pivotal role in facilitating the metastasis of oral squamous cell carcinoma (OSCC). This is achieved by their dynamic influence on reshaping the tumor's immune microenvironment, thereby enhancing its metastatic potential. More details can be found in article number 2400524 by Liang Dong, Xiang Chen, Anjie Min, Mingzhu Yin, and co-workers.