Integrating Single‐Cell and Spatial Transcriptomics Reveals Heterogeneity of Early Pig Skin Development and a Subpopulation with Hair Placode Formation (Adv. Sci. 20/2024)

Spatial Transcriptomes Pigs are a valuable resource for human medical research. The cover shows a high-resolution spatial-temporal transcriptome atlas of pig skin was constructed and various cell types were captured by spots array of spatial transcriptomes. The results indicate notable similarities between pigs and humans in early skin development. Furthermore, by comparing normal and hairless pigs, the study reveals a cell subpopulation causing lower hair placode density and further hairless in pigs. This work provides a valuable resource for further investigation into hair follicle development and the etiology of human skin diseases, utilizing the porcine model system. More details can be found in article number 2306703 by Yi Wang, Yao Jiang, Xiangdong Ding, and co-workers.