High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration (Adv. Sci. 17/2024)

Diabetic Bone Regeneration Inspired by the correlation between endoplasmic reticulum (ER) dysfunction and osteogenesis disorder, Yulan Liu, Mingliang Zhou, Xinquan Jiang, and co-workers propose in article number 2309491 a novel therapeutic platform comprising a high-performance hydrogel and engineered exosomes to maintain ER homeostasis and accelerate diabetic bone regeneration. The ER-based therapy effectively regulates the overload stress and functional alterations arising from hyperglycemia and establishes an optimum intracellular microenvironment for osteogenesis in diabetic conditions, showing potential for clinical translation.