Selective Suppression of Integrin‐Ligand Binding by Single Molecular Tension Probes Mediates Directional Cell Migration (Adv. Sci. 14/2024)
Source abstract
Abstract
Focal Adhesion Kinase Phosphorylation In article number 2306497, Dong-Hwee Kim and co-workers report a novel method for selectively controlling a molecular binding force between intracellular protein integrin and extracellular matrix ligand protein in a pN scale, using a rupture force of double strand DNA. They demonstrate such a miniscule change of binding force can lead directional cell migration by phosphorylation of focal adhesion kinase (FAK).
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cell Adhesion Molecules Research · Cellular Mechanics and Interactions · Silk-based biomaterials and applications
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