Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment (Adv. Sci. 13/2024)

Advanced Janus Film for Periodontitis Treatment In article number 2305756, Xuehui Zhang, Xue Qu, and co-workers report a salt effect modulated electro-assembly technique for collagen film to customize its porous microstructures and functional salt components. This water-based fabrication method is simple, fast, and enables programmable creation of collagen films with controlled porosity, pore size and salt composition. Specifically, a customized bioactive Janus film with a dense and an anti-inflammatory drug modulated porous layer is constructed using a sequentially electro-assembly for periodontitis treatment application. The coupling of porous microstructures and specific anti-inflammatory composition inside the Janus film provides asymmetric cellular regulations and synergistically immunomodulatory functions, demonstrates a potential for inflammation suppression and alveolar bone regeneration promotion.