Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia (Adv. Sci. 12/2024)

Yingying Yu; Yunxing Su; Sisi Yang; Yutong Liu; Zhiting Lin; Nupur K. Das; Qian Wu; Jiahui Zhou; Shumin Sun; Xiaopeng Li; Wuyang Yue; Yatrik M. Shah; Junxia Min; Fudi Wang

doi:10.1002/advs.202470067

journal article·2024-03Open access

Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia (Adv. Sci. 12/2024)

Yingying Yu, Yunxing Su, Sisi Yang, Yutong Liu, Zhiting Lin, Nupur K. Das, Qian Wu, Jiahui Zhou, Shumin Sun, Xiaopeng Li, Wuyang Yue, Yatrik M. Shah, Junxia Min, Fudi Wang

Advanced Science· Volume 11· Issue 12

Publisher page Open full text

Source abstract

Abstract

Iron-Refractory Anemia In article number 2307022, Yatrik M. Shah, Junxia Min, Fudi Wang, and co-workers show hypoxia and the HIF-PH inhibitor as anemia novel therapies through Hif2α (phoenix) mediated transcriptional upregulation of Fpn (dragon) in the intestinal villi (mountains). Increased Fpn transports more iron into the circulation (depicted by the dragon's breath), thereby treating anemia (red blood cell). The illustration is inspired by the Year of the dragon 2024 and the traditional Chinese story of “The Auspicious Dragon and Phoenix”, symbolic creatures that represent good fortune.

Source: openalex_inverted_index · Quality: baseline

Research context

Ceramics & glasses

OpenAlex topics: Erythropoietin and Anemia Treatment · Hydrogen's biological and therapeutic effects · Iron Metabolism and Disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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