An Alternating Current Electroosmotic Flow‐Based Ultrasensitive Electrochemiluminescence Microfluidic System for Ultrafast Monitoring, Detection of Proteins/miRNAs in Unprocessed Samples (Adv. Sci. 6/2024)

Portable Electrochemiluminescence Microfluidic Devices In article number 2307840, Hui Chen, Huali Shen, Jilie Kong, Xueen Fang, and co-workers report an ultrasensitive, rapid and portable electrochemiluminescence-microfluidic (ECL-M) system based on alternating current electroosmotic flow for diagnosis of acute myocardial infarction (AMI). The effectiveness of monitoring the peak expression levels of cTnI and miR-499-5p for AMI in rats has been found to be greater in saliva than in serum and biotic fluids. This suggests that saliva has the potential to serve as a replacement sample source for POCT in the diagnosis of AMI. This system is meticulously designed to serve army battlefields, underfunded hospitals, and patients without professional expertise. The ECL-M POCT device has the potential for extensive development beyond heart-related diseases, as it can accommodate a wider range of sample types and sources. This advancement in technology can significantly enhance the accuracy of disease diagnosis.