Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures (Adv. Sci. 4/2024)

Stem Cell-Based Embryo Models Article number 2304987 by Vinidhra Shankar, Clemens van Blitterswijk, Erik Vrij, and Stefan Giselbrecht shows a continuous culture and in situ imaging of 3D stem cell-derived embryo-like structures in microwell arrays. The automated screening and analysis of key morphological features via a supervised machine learning pipeline creates a unique opportunity to quantitatively and systematically study effects of pathway modulators on early embryonic development.