In Situ Neutralization and Detoxification of LPS to Attenuate Hyperinflammation (Adv. Sci. 26/2023)

Lipopolysaccharide Hyperinflammation elicited by lipopolysaccharide (LPS) that derives from Gram-negative pathogens, leads to a sharp increase in mortality globally. In article number 2302950, Xiaoyu Li, Jianzhong Shen, Kui Zhu, and co-workers have designed an all-in-one drug delivery system equipped with bactericidal activity, LPS neutralization and detoxification to recognize, kill pathogens, and attenuate hyperinflammation through abolishing the activation of LPS triggered acute inflammatory responses.