Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023)

Biofabricate Lung Tumors In article number 2206603 by Mien-Chie Hung, Der-Yang Cho, Yi-Wen Chen, and co-workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxygen gradient, as well as biophysical and biochemical behaviors of the native tumors is established. This model demonstrates the excellent prediction results (accuracy: 85%; sensitivity: 86.7% and specificity: 80%) for applying in patient-specific precision therapies.