Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
Source abstract
Abstract
Vesicle Fusion In article number 2206823, using the bottom-up synthetic reconstitution, electron microscopy, and in-vivo amperometry, Yongsoo Park and co-workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotagmin-1 insertion, thereby lowering the energy barrier for Ca2+-dependent fusion to occur.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lipid Membrane Structure and Behavior
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