Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co-workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease-protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression.