Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)

Actin Dynamics In article number 2204896, a novel role of the formin FMNL2 is uncovered by Dennis Frank, Christel Jessica Moussi, Carsten Schwan, Robert Grosse, and co-workers. TGFβ-induced processes, such as cell invasion and the secretion and trafficking of the pro-metastatic factor ANGPTL4 require phospho-activated FMNL2. Live cell super-resolution microscopy allows the observation of FMNL2 directly polymerizing actin at motile ANGPTL4-containing vesicles. A time course of FMNL2 (green) and actin polymerization (cyan) at an ANGPTL4 vesicle (magenta) is shown, starting from the association of FMNL2 (top left) and ending with the dissociation of the formin (bottom right).