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journal article·2023-02Open access

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023)

Mostafa M. Hamed, Ahmed S. Abdelsamie, Katharina Rox, Christian Schütz, Andreas M. Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce‐Rodriguez, José Manuel Borrero‐de Acuña, Dieter Jahn, Jessica Rademacher, Felix C. Ringshausen, Nina Cramer, Burkhard Tümmler, Anna K. H. Hirsch, Rolf W. Hartmann, Martin Empting

Advanced Science· Volume 10· Issue 5
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Source abstract

Abstract

Quorum Sensing Inhibitor In article number 2204443, Martin Empting and colleagues describe the medicinal-chemistry-driven discovery of a new quorum sensing inhibitor (QSI) against Pseudomonas aeruginosa. The discovered QSI synergized with standard-of-care antibiotic tobramycin in a murine infection model providing an in vivo proof-of-concept.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bacterial biofilms and quorum sensing · Biochemical and Structural Characterization · Antibiotic Resistance in Bacteria

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