Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
Source abstract
Abstract
Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show decreased β cell death and macrophage infiltration, comparable to healthy wild‐type animals, as depicted in the photo. [Image: see text]
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Pancreatic function and diabetes · Diabetes and associated disorders · Diabetes Management and Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References
Reference metadata was not supplied for this record.