Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
Source abstract
Abstract
Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and thus could be rescued by the modulation of SIRT1 levels in each neuron and brain endothelial cell. [Image: see text]
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Research context
OpenAlex topics: Neurological Disease Mechanisms and Treatments · Neurological Disorders and Treatments
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