Experimental Autoimmune Encephalomyelitis: In Vivo Induction of Regulatory T Cells Via CTLA‐4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse (Adv. Sci. 14/2021)

In article number 2004973, Je‐Min Choi and co‐workers develop a synthetic peptide dNP2‐ctCTLA‐4 that regulates experimental autoimmune encephalomyelitis progression and relapse in the longterm by inducing Foxp3(+) Treg cells in vivo. This peptide induces Treg cells in human peripheral blood mononuclear cells from multiple sclerosis (MS) patients and in a humanized mouse model, demonstrating that it would be a novel therapeutic agent for MS. [Image: see text]