Autophagy Intervention Agents: Iron Oxide Nanoparticles as Autophagy Intervention Agents Suppress Hepatoma Growth by Enhancing Tumoricidal Autophagy (Adv. Sci. 16/2020)

In article number 1903323, Peifeng Liu and co‐workers identify the carboxy‐functional iron oxide nanoparticle (Fe(2)O(3)@DMSA) as an autophagy intervention agent for the treatment of hepatoma. In‐depth analysis reveals that Fe(2)O(3)@DMSA triggers intracellular iron‐retention‐induced sustained reactive oxygen species production to activate autophagy but block the fusion of autophagosomes and lysosomes, which efficiently inhibits hepatoma growth through enhancing tumoricidal autophagy in vitro and in vivo. Fe(2)O(3)@DMSA shows potential clinical application for hepatoma therapy. [Image: see text]