Neoantigen Tracking: Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer (Adv. Sci. 9/2020)

Qingzhu Jia; Luting Chiu; Shuangxiu Wu; Jian Bai; Lina Peng; Linpeng Zheng; Rui Zang; Xueqin Li; Bibo Yuan; Yixing Gao; Dingyong Wu; Xiaohong Li; Lin Wu; Jianguo Sun; Ji He; Bruce W. S. Robinson; Bo Zhu

doi:10.1002/advs.202070047

journal article·2020-05Open access

Neoantigen Tracking: Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer (Adv. Sci. 9/2020)

Qingzhu Jia, Luting Chiu, Shuangxiu Wu, Jian Bai, Lina Peng, Linpeng Zheng, Rui Zang, Xueqin Li, Bibo Yuan, Yixing Gao, Dingyong Wu, Xiaohong Li, Lin Wu, Jianguo Sun, Ji He, Bruce W. S. Robinson, Bo Zhu

Advanced Science· Volume 7· Issue 9

Publisher page Open full text

Source abstract

Abstract

Inter-individual heterogeneity of the mutational spectrum is the major obstacle of effective in vivo monitoring of mutation-directed T cell killing by ctDNA sequencing. In article number 1903410, Jianguo Sun, Bo Zhu, and co-workers develop a customized sequencing strategy that mainly targets predicted neoantigen-coding mutations. This work significantly broadens the coverage of ctDNA sequencing and is expected to improve personalized management strategies optimizing the clinical benefits of checkpoint immunotherapies.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Genomics and Diagnostics · Cancer Immunotherapy and Biomarkers · Immunotherapy and Immune Responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Cancer Xinqiao Hospital The Army Medical University Xinqiao Main Street Chongqing 400037 China

Chongqing Key Laboratory of Immunotherapy Xinqiao Main Street Chongqing 400037 China

Berry Oncology Corporation NO. 4 Science Park Road, Changping District Beijing 102206 China

GeneCast Biotechnology Co., Ltd. 35 Huayuan North Road, HealthWork Suite 901 Beijing 100191 China

School of Medicine and Pharmacology University of Western Australia 35 Stirling Highway Perth Western Australia 6009 Australia

National Centre for Asbestos Related Diseases GPO Box U1908 Perth Western Australia 6845 Australia

References

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