DataVXAdvanced SciencePaper
journal article·2020-04Open access

Arterial Regeneration: Dimeric Thymosin β4 Loaded Nanofibrous Interface Enhanced Regeneration of Muscular Artery in Aging Body through Modulating Perivascular Adipose Stem Cell–Macrophage Interaction (Adv. Sci. 8/2020)

Wanli Chen, Sansan Jia, Xinchi Zhang, Siqian Zhang, Huan Liu, Xin Yang, Cun Zhang, Wei Wu

Advanced Science· Volume 7· Issue 8
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Source abstract

Abstract

In article number 1903307, Cun Zhang, Wei Wu, and co-workers identify the adult perivascular adipose tissue (PVAT) as the dominant source of vascular progenitors in a rat abdominal aorta model and clarify the mechanism by which DTβ4 enhances arterial muscle remodeling in the aging body. Different from conventional synthetic grafts, DTβ4-incorporated grafts exhibit enhanced vascular regenerative activity and effectively ameliorate aging induced defective regeneration, thus providing a rational strategy for clinical translation of vascular grafts.
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Research context

Nanomaterials

OpenAlex topics: Cardiovascular Disease and Adiposity · Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology Department of Oral & Maxillofacial Surgery School of Stomatology the Fourth Military Medical University Xi'an Shaanxi China

Department of Pathophysiology Institute of Basic Medical Science Xi'an Medical University Xi'an China

State Key Laboratory of Cancer Biology Biotechnology Center School of Pharmacy the Fourth Military Medical University Xi'an China

References

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