DataVXAdvanced SciencePaper
journal article·2020-03Open access

Antibiotic Resistance: Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA (Adv. Sci. 6/2020)

Jie Hui, Pu‐Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Erlinda R. Ulloa, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Mohamed N. Seleem, George Y. Liu, Qiang Cui, Ji‐Xin Cheng

Advanced Science· Volume 7· Issue 6
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Source abstract

Abstract

In article number 1903117, Ji-Xin Cheng and co-workers report an endogenous chromophore-based phototherapy platform to combat antibiotic-resistance Staphylococcus aureus infections. Functional membrane microdomains of Staphylococcus aureus are catastrophically disrupted via photochemical decomposition of membrane-bound carotenoid pigment, staphyloxanthin, thus reviving a broad spectrum of conventional antibiotics against Staphylococcus aureus.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Advanced Nanomaterials in Catalysis

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Affiliations

Department of Electrical and Computer Engineering Boston University Boston MA 02215 USA

Boston University Photonics Center Boston MA 02215 USA

Department of Chemistry Boston University Boston MA 02215 USA

State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical Chemistry Jilin University Changchun 130012 China

Collaborative to Halt Antibiotic‐Resistant Microbes (CHARM) Department of Pediatrics University of California San Diego School of Medicine La Jolla CA 92093 USA

Division of Infectious Disease Department of Pediatrics Children's Hospital of Philadelphia Philadelphia PA 19104 USA

Department Biomedical Engineering Boston University Boston MA 02215 USA

College of Veterinary Medicine Purdue University West Lafayette IN 47907 USA

Division of Infectious Diseases Rady Children's Hospital San Diego CA 92123 USA

References

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