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journal article·2020-02Open access

Cell Delivery: Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag (Adv. Sci. 4/2020)

Norbert Imre, Anasztázia Hetényi, Enikő Szabó, Brigitta Bodnár, Abel Szkalisity, Ilona Gróf, Alexandra Bocsik, Mária A. Deli, Peter Horvath, Ágnes Czibula, Éva Monostori, Tamás A. Martinek

Advanced Science· Volume 7· Issue 4
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Source abstract

Abstract

In article number 1902621, Tamás A. Martinek and co-workers develop a pentapeptidic tag, which reads the glycan code of ganglioside GM1 and triggers lipid raft-mediated endocytosis, avoiding lysosomal entrapment. This carrier molecule can deliver macromolecular cargoes (e.g., IgG complexes) into live cells with the possibility to escape to the cytosol.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Glycosylation and Glycoproteins Research · Biochemical and Structural Characterization · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical Chemistry University of Szeged Dóm tér 8 Szeged HU‐6720 Hungary

Institute of Genetics Biological Research Center (BRC) Temesvári krt. 62 Szeged HU‐6726 Hungary

Synthetic and Systems Biology Unit Biological Research Center (BRC) Temesvári krt. 62 Szeged HU‐6726 Hungary

Institute of Biophysics Biological Research Center (BRC) Temesvári krt. 62 Szeged HU‐6726 Hungary

Doctoral School of Biology University of Szeged Dugonics tér 13 Szeged HU‐6720 Hungary

Department of Cell Biology and Molecular Medicine University of Szeged Somogyi u. 4 Szeged HU‐6720 Hungary

Institute for Molecular Medicine Finland University of Helsinki Tukholmankatu 8 Helsinki FI‐00014 Finland

References

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