DataVXAdvanced SciencePaper
journal article·2019-12Open access

Parkinson's Disease: Extracellular Nanomatrix‐Induced Self‐Organization of Neural Stem Cells into Miniature Substantia Nigra‐Like Structures with Therapeutic Effects on Parkinsonian Rats (Adv. Sci. 24/2019)

Shiqing Zhang, Peng Sun, Kaili Lin, Florence Hiu Ling Chan, Qi Gao, Wai Fung Lau, Vellaisamy A. L. Roy, Hongqi Zhang, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yung

Advanced Science· Volume 6· Issue 24
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Source abstract

Abstract

In article number 1901822, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yung, and co-workers develop a biocompatible silica sculptured in nanozigzags by glancing angle deposition. The nanomatrix induces self-organization of neural stem cells into miniature substantia nigra-like brain structures, which could deliver early and progressive amelioration in Parkinsonian rats. These results provide significant insight into novel cell therapies for Parkinson's disease.
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Research context

NanomaterialsBiomaterialsMaterials processing

OpenAlex topics: Graphene and Nanomaterials Applications

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Affiliations

Department of Biology Hong Kong Baptist University (HKBU) Kowloon Tong Kowloon Hong Kong SAR China

Golden Meditech Center for NeuroRegeneration Sciences HKBU Kowloon Tong Kowloon Hong Kong SAR China

HKBU Institute of Research and Continuing Education, 9F The Industrialization Complex of Shenzhen Virtual University Park No. 2 Yuexing 3rd Road, South Zone, Hi‐tech Industrial Park, Nanshan District Shenzhen 518057 Guangdong Province China

Department of Physics HKBU Kowloon Tong Kowloon Hong Kong SAR China

Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518000 Guangdong Province China

Department of Biomedical Engineering City University of Hong Kong (CityU) Tat Chee Avenue, Kowloon Tong Kowloon Hong Kong SAR China

Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue, Kowloon Tong Kowloon Hong Kong SAR China

School of Chinese Medicine HKBU Kowloon Tong Kowloon Hong Kong SAR China

Institute of Advanced Materials State Key Laboratory of Environmental and Biological Analysis HKBU Kowloon Tong Kowloon Hong Kong SAR China

References

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