Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
Source abstract
Abstract
In article number 1901299, Chunsheng Kang and co-workers demonstrate the collateral effect of the CRISPR-Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR-Cas13a system induces death in EGFRvIII-overexpressing glioma cells. Furthermore, CRISPR-Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: CRISPR and Genetic Engineering · RNA regulation and disease · Pluripotent Stem Cells Research
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Affiliations
Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post‐neurotrauma Neuro‐repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China
Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China
Department of Pathology Medical College of Hebei University Baoding Hebei 071000 China
References
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