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journal article·2019-09Open access

Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019)

Kai Huang, Xing Liu, Yansheng Li, Qixue Wang, Junhu Zhou, Yunfei Wang, Feng Dong, Chao Yang, Zhiyan Sun, Chuan Fang, Chaoyong Liu, Yanli Tan, Xudong Wu, Tao Jiang, Chunsheng Kang

Advanced Science· Volume 6· Issue 17
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Source abstract

Abstract

In article number 1900782, Xudong Wu, Tao Jiang, and Chunsheng Kang, and co-workers present a genome-wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 library. Notably, E2F6 was proven to drive the temozolomide (TMZ) resistance of 191 glioblastoma-related candidate genes. To silence the expression of E2F6 is a promising strategy to conquer TMZ resistance in glioblastoma.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: CRISPR and Genetic Engineering · Glioma Diagnosis and Treatment · Mycobacterium research and diagnosis

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Affiliations

Tianjin Neurological Institute Key Laboratory of Post‐Neurotrauma Neuro‐Repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Tianjin 300052 China

Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Beijing Neurosurgical Institute Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Department of Cell Biology 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Key Laboratory of Medical Epigenetics Tianjin Medical University Tianjin 300070 China

Department of Neurosurgery Affiliated Hospital of Hebei University Baoding 071000 China

Department of Pathology Affiliated Hospital of Hebei University Baoding 071000 China

References

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