Single‐Cell Cytokine Assays: Multiplexed, Sequential Secretion Analysis of the Same Single Cells Reveals Distinct Effector Response Dynamics Dependent on the Initial Basal State (Adv. Sci. 9/2019)
Source abstract
Abstract
In article number 1801361, Yao Lu, Rong Fan, and co-workers demonstrate a multiplexed antibody-barcode-integrated microtrough array chip, that sequentially measures protein secretions from >5000 single macrophage cells upon activation. The protein secretion dynamics classifies them into two major activation states dependent on the basal state of each cell, showing a cell-intrinsic heterogeneous response in a phenotypically homogeneous cell population.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Biosensing Techniques and Applications
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Affiliations
Department of Biomedical Engineering Yale University New Haven CT 06520 USA
Department of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 China
Department of Genetics Yale School of Medicine New Haven CT 06520 USA
Yale Stem Cell Center New Haven CT 06520 USA
Yale Cancer Center New Haven CT 06520 USA
References
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