Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
Source abstract
Abstract
In article 1801531, Rong Fan and co-workers examine the dynamics of brain tumor cells in a microvasculature-on-a-chip system. Tumor cells residing in the perivascular zone show various degrees of co-localization with microvessels across ten glioblastoma patients. Single-cell transcriptome sequencing (21 750 single cells) reveals that brain tumor cells with high expression of PDGFRA preferentially localize in the perivascular niche.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research
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Affiliations
Department of Biomedical Engineering Yale University New Haven CT 06520 USA
School of Computer Science Carnegie Mellon University Pittsburgh PA 15213 USA
Applied Math Program Yale University New Haven CT 06520 USA
Department of Neurosurgery Yale School of Medicine New Haven CT 06520 USA
Department of Pathology Indiana University Health Pathology Laboratory Indianapolis IN 46202 USA
Yale Comprehensive Cancer Center New Haven CT 06520 USA
References
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