DataVXAdvanced SciencePaper
journal article·2019-03Open access

Neuron–Muscle Interfaces: Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction (Adv. Sci. 6/2019)

Eunkyung Ko, Seung Jung Yu, Gelson J. Pagan‐Diaz, Ziad Mahmassani, Marni D. Boppart, Sung Gap Im, Rashid Bashir, Hyunjoon Kong

Advanced Science· Volume 6· Issue 6
Publisher pageOpen full text
Source abstract

Abstract

In article number 1801521, Hyunjoon Kong and co-workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed on grooved substrates. The motor neurons innervate more actively to the mature myotubes formed on the 1600 nm groove width. Accordingly, those myotubes respond more rapidly to neurotransmitter and neuromuscular antagonists. The results of this study will be useful for improving the quality of engineered muscle used in applications such as drug screening, regeneration therapies, and biological machinery assembly.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research · Tissue Engineering and Regenerative Medicine

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Affiliations

Department of Bioengineering University of Illinois at Urbana–Champaign Urbana IL 61801 USA

Department of Bioengineering Micro and Nanotechnology Laboratory University of Illinois at Urbana–Champaign Urbana IL 61801 USA

Department of Chemical and Biomolecular Engineering and KI for the Nano Century Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305‐701 Republic of Korea

Department of Kinesiology and Community Health Beckman Institute for Advanced Science and Technology University of Illinois at Urbana–Champaign Urbana IL 61801 USA

Carl R. Woese Institute for Genomic Biology and Beckman Institute for Advanced Science and Technology University of Illinois at Urbana–Champaign Urbana IL 61801 USA

Carle Illinois College of Medicine University of Illinois at Urbana–Champaign Urbana IL 61801 USA

Department of Chemical and Biomolecular Engineering University of Illinois at Urbana–Champaign Urbana IL 61801 USA

References

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