DataVXAdvanced SciencePaper
journal article·2018-02Open access

Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)

Li Fan, Silu Zhang, Chunyuan Zhang, Chun Yin, Zhiqin Chu, Chaojun Song, Ge Lin, Quan Li

Advanced Science· Volume 5· Issue 2
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Source abstract

Abstract

The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number 1700289, Quan Li and co-workers demonstrate the feasibility of using self-decomposable nanoparticle drug carriers as intracellular drug reservoirs that enable delivery of a stable therapeutic concentration, leading to complete reversal of multidrug resistance.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Analysis The Fourth Military Medical University 169th Changle west road Xi'an Shaanxi 710032 China

Department of Physics The Chinese University of Hong Kong Shatin New Territories Hong Kong

Beijing Computational Science Research Center No.10 East Xibeiwang Road Haidian District Beijing 100193 China

School of Biomedical Sciences The Chinese University of Hong Kong Shatin New Territories Hong Kong

Department of Immunology The Fourth Military Medical University 169th Changlewest road Xi'an Shaanxi 710032 China

References

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