DataVXAdvanced SciencePaper
journal article·2018-08Open access

Trimodal Therapy: A Tumor Vascular‐Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia (Adv. Sci. 8/2018)

Xin Luan, Ying‐Yun Guan, Hai‐Jun Liu, Qin Lu, Mei Zhao, Duxin Sun, Jonathan F. Lovell, Peng Sun, Hong‐Zhuan Chen, Chao Fang

Advanced Science· Volume 5· Issue 8
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Source abstract

Abstract

A tumor vascular-targeted interlocking trimodal nanosystem that induces and exploits hypoxia is described by Hong-Zhuan Chen, Chao Fang, and co-workers in article number 1800034. In the image, the two streams of water from bamboo pipes and the rotary waterwheel are shown to represent verteporfin for vascular-targeted photodynamic treatment and HIF-1α siRNA for elevated activating reductases (CYP450), which can trigger the activation of AQ4N (a hypoxia-activated prodrug).
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer, Hypoxia, and Metabolism · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hongqiao International Institute of Medicine Shanghai Tongren Hospital and Department of Pharmacology and Chemical Biology Institute of Medical Sciences Shanghai Jiao Tong University School of Medicine (SJTU‐SM) 280 South Chongqing Road Shanghai 200025 China

Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Ann Arbor MI 48105 USA

Institute of Interdisciplinary Integrative Biomedical Research Shanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201210 China

Department of Pharmacy Ruijin Hospital SJTU‐SM, 197 Rui Jin Er Road Shanghai 200025 China

Department of Pharmacy Shanghai University of Medicine & Health Sciences 279 Zhouzhu Road Shanghai 201318 China

Department of Biomedical Engineering University at Buffalo State University of New York Buffalo NY 14260 USA

Department of General Surgery Shanghai Tongren Hospital SJTU‐SM, 1111 Xianxia Road Shanghai 200336 China

References

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