Novel Insights into Enzymatic Thermostability: The “Short Board” Theory and Zero‐Shot Hamiltonian Model (Adv. Sci. 45/2024)

The “Short Board” Theory for Enzymatic Thermostability The “short board” effect concept suggests that the targeting of critical weak regions within proteins plays a crucial role in determining the upper threshold of enzymatic stability and holds significant potential for enhancing enzyme thermostability. This is analogous to Sun Wukong's return after acquiring knowledge, with the golden cudgel serving as the core factor in his transformation into the Monkey King. More details can be found in article number 2402441 by Tao Tu, Haobo Wang, and co-workers.