DataVXAdvanced SciencePaper
journal article·2024-05Open access

Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease (Adv. Sci. 20/2024)

You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N. Diep, Khanh V. Do, Yeji Jeon, Dong‐Gyu Jo, C. Justin Lee, Mathew Blurton‐Jones, Hoon Ryu, Hansang Cho

Advanced Science· Volume 11· Issue 20
Publisher pageOpen full text
Source abstract

Abstract

Alzheimer's Diseases In article number 2304357, Hansang Cho and co-workers investigate neurotoxic microgliosis in Alzheimer's disease (AD). This study reveals that AD neuron-reactive astrocyte interaction induces production of key cytokine (IFNγ) and accumulation of oxidative stress (H2O2), which activate proinflammatory microglia. The proinflammatory microglia in tern exacerbate synaptic impairment, phosphorylated-tau accumulation, and neuronal loss at the end. The cover was illustrated by You Jung Kang.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Neuroinflammation and Neurodegeneration Mechanisms · Tryptophan and brain disorders · Genomics, phytochemicals, and oxidative stress

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References

Reference metadata was not supplied for this record.