ANPELA: Significantly Enhanced Quantification Tool for Cytometry‐Based Single‐Cell Proteomics (Adv. Sci. 15/2023)

Single-Cell Proteomics Single-cell proteomics provides an unprecedented view of cellular heterogeneity at the single-cell resolution, enabling a better understanding of biological mechanisms. In article number 2207061, Ying Zhang, Huaicheng Sun, Feng Zhu, and co-workers develop ANPELA, a significantly enhanced quantification tool that facilitates the analysis of high-dimensional single-cell proteome expression data and the identification of cell populations with distinct static or pseudo-temporal phenotypes. This work sheds light on the importance of accurate quantification and proper data processing in advancing single-cell proteomics research.