Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)

T Cell homeostasis The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co-workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinflammatory diseases. Accordingly, chemical or genetic inhibition of necroptosis signaling can ameliorate the inflammatory damage by Rpa1 deficiency and restore host immune homeostasis.