Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy (Adv. Sci. 3/2023)

Smart Supramolecular Peptides In article number 2203351, Lei Wang, Hao Wang, Bo Hu, and co-workers report the formulation of a smart supramolecular peptide (SSP) eye drop for diabetic retinopathy treatment that is effective via specifically identifying and capturing Semaphorin4D (Sema 4D), a strongly pro-angiogenesis and exudates factor. The combination of SSP eye drop and anti-vascular endothelial growth factor (VEGF) injection showed approximately two times better therapeutic effect over anti-VEGF treatment alone. This work provides an alternative and effective method for noninvasive treatment for diabetic retinopathy.