DataVXAdvanced SciencePaper
journal article·2020-01Open access

Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020)

Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang, Hélder A. Santos, Hongxing Shen

Advanced Science· Volume 7· Issue 1
Publisher pageOpen full text
Source abstract

Abstract

In degenerative diseases, microenvironment deterioration is often followed by a vicious circle of cell death and aggravation of microenvironment deterioration. To break the cycle, a gene-hydrogel microenvironment is constructed in article number 1902099 by Yuhui Zhang, Hélder A. Santos, Hongxing Shen, and co-workers in situ, which regulates the synthesis/catabolism balance of extracellular matrix in the nucleus pulposus of the intervertebral disc and improves the tissue microenvironment regeneration.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Spine and Intervertebral Disc Pathology · Medical Imaging and Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Spine Surgery Renji Hospital Shanghai JiaoTong University School of Medicine 160 Pujian Road Shanghai 200127 P. R. China

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. China

Pharmaceutical Sciences Laboratory and Turku Bioscience Center Åbo Akademi University Turku FI‐20520 Finland

Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland

Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki FI‐00014 Finland

References

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